SPRAVATO®
(esketamine)
WHAT IS SPRAVATO®?
SPRAVATO® is the only FDA-approved nasal spray for adults with treatment-resist depression that can be taken with or without an oral antidepressant, giving you more options and flexibility.
If you have taken two or more oral antidepressants and still experience symptoms of depression, you may have treatment-resistant depression.
HOW DOES SPRAVATO® WORK?
Most antidepressants work on serotonin, dopamine and norephrine. SPRAVATO® is different – it targets NMDA receptors in the brain’s glutamate system, which plays a key role in communication between brain cells. In depression, communication between brain cells can become slowed or blocked. SPRAVATO® helps restore those connections quickly, allowing the brain pathways to “reset,” which leads to improved mood, energy and functioning in a shorter time frame.
WHAT TO EXPECT DURING SPRAVATO® TREATMENT?
You will administer SPRAVATO® nasal spray yourself under the supervision of a healthcare provider at Interventional Psychiatry Group.
After you administer SPRAVATO®,there will be an observation period of at least 2 hours, during which you will rest comfortably while a healthcare provider at Interventional Psychiatry Group monitors you for possible side effects.
Because of possible side effects affecting mental alertness and motor coordination, you won’t be able to drive, operate machinery, or do anything where you need to be completely alert until the next day, following a restful sleep.
HOW TO PREPARE FOR SPRAVATO® TREATMENT DAYS?
Avoid eating 2 hours before, and drinking liquids 30 minutes before, the treatment session. Some patients taking SPRAVATO® may experience nausea or vomiting.
If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least 1 hour before taking SPRAVATO®.
Many people spend the observation time relaxing, listening to music, reading, or resting.
What are the possible side effects of Spravato®?
The Most Common Side Effects of Spravato®:
 Feeling disconnected from yourself. |
 Feeling anxious. |
 Nausea |
 Lack of energy. |
 Feeling sleepy |
 Increased blood pressure. |
 Spinning sensation |
 Decreased feeling of sensitivity. (Numbness) |
 Feeling drunk. |
 Headache. |
 Feeling very happy or excited. |
 Vomiting |
Your Safety Comes First
Every SPRAVATO® treatment is supervised in our clinic by experienced medical staff. We check your blood pressure before SPRAVATO® administration, 40-minutes after administration and finally two hours after administration.
READY TO TAKE THE NEXT STEPS?
Choosing SPRAVATO® can fell like a big decision —
and we’re here to walk with you through every stage.
Here’s what you can expect:
You will meet with one of our providers for a full psychiatric evaluation. Together you will review your treatment history and confirm eligibility for SPRAVATO®. Discuss your goals, concerns, and expectations. Outline a personalized treatment schedule.
You don’t have to do this alone. Our team will handle the insurance, the authorizations, and the details — so you can focus on healing.
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